DegronMD

Uniprot ID: Q9Y230

Source protein: RuvB-like 2

Source gene: RUVBL2

Class: DEG_COP1_1

Location: 5:13

E3 ligase: COP1

DEGRON score: 0.7378

ASA_SCORE: 95.0333

COIL: 0.8892

CONS_SCORE: 0.3389

DSS_SCORE: 0.5147

HELIX: 0.0273

FCONS_SCORE: 0.6425

RIG_SCORE: 0.821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11L	TCGA-B5-A3FC	UCEC	TCGA	TATTKVPEI	DEG_COP1_1	0.7582
p.P11L	DO41871	UCEC	ICGC	TATTKVPEI	DEG_COP1_1	0.7582
p.R14H	TCGA-CK-6746	COAD	TCGA	TATTKVPEI	DEG_COP1_1	0.3056
p.R14H	DO7938	COAD	ICGC	TATTKVPEI	DEG_COP1_1	0.3056
p.P11S	TCGA-EE-A2GR	SKCM	TCGA	TATTKVPEI	DEG_COP1_1	0.6752
p.P11S	DO37996	SKCM	ICGC	TATTKVPEI	DEG_COP1_1	0.6752
p.V16L	DO229036	LICA	ICGC	TATTKVPEI	DEG_COP1_1	0.25
p.R14C	SIDM01088	Endometrial Carcinoma	GDSC	TATTKVPEI	DEG_COP1_1	0.3056
p.R14C	ACH-000965	Endometrial/Uterine Cancer	CCLE	TATTKVPEI	DEG_COP1_1	0.3056
p.R14C	RL95-2	endometrium	COSMIC	TATTKVPEI	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y230	RuvB-like 2	DEG_COP1_1	5:13	TATTKVPEI	COP1	0.7378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons