DegronMD

Uniprot ID: Q6FIF0

Source protein: AN1-type zinc finger protein 6

Source gene: ZFAND6

Class: DEG_COP1_1

Location: 67:74

E3 ligase: COP1

DEGRON score: 0.9808

ASA_SCORE: 71.3375

COIL: 0.7884

CONS_SCORE: 0.2887

DSS_SCORE: 0.6128

HELIX: 0.1554

FCONS_SCORE: 0.9858

RIG_SCORE: 0.6624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D68H	TCGA-77-6842	LUSC	TCGA	TDGSVPEA	DEG_COP1_1	0.7688
p.D68H	DO27413	LUSC	ICGC	TDGSVPEA	DEG_COP1_1	0.7688
p.S70G	TCGA-D3-A2JO	SKCM	TCGA	TDGSVPEA	DEG_COP1_1	0.5882
p.S70G	DO47619	SKCM	ICGC	TDGSVPEA	DEG_COP1_1	0.5882
p.D68N	TCGA-DK-A6B2	BLCA	TCGA	TDGSVPEA	DEG_COP1_1	0.6932
p.D68N	DO48543	BLCA	ICGC	TDGSVPEA	DEG_COP1_1	0.6932
p.S84F	TCGA-ZF-A9R7	BLCA	TCGA	TDGSVPEA	DEG_COP1_1	0.0556
p.S84F	DO219064	BLCA	ICGC	TDGSVPEA	DEG_COP1_1	0.0556
p.Q75L	DO229253	THCA	ICGC	TDGSVPEA	DEG_COP1_1	0.3056
p.T67K	DO229242	THCA	ICGC	TDGSVPEA	DEG_COP1_1	0.7306
p.S76G	SW1783	central_nervous_system	COSMIC	TDGSVPEA	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6FIF0	AN1-type zinc finger protein 6	DEG_COP1_1	67:74	TDGSVPEA	COP1	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons