DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TEDPVPEA
Uniprot ID:
Q86VX2
Source protein:
COMM domain-containing protein 7
Source gene:
COMMD7
Class:
DEG_COP1_1
Location:
7:14
E3 ligase:
COP1
DEGRON score:
0.8906
ASA_SCORE:
79.9125
COIL:
0.7389
CONS_SCORE:
0.425
DSS_SCORE:
0.5861
HELIX:
0.2456
FCONS_SCORE:
0.8866
RIG_SCORE:
0.7305
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P12S
DO233737
GACA
ICGC
TEDPVPEA
DEG_COP1_1
0.6752
p.L22M
ACH-000930
Breast Cancer
CCLE
TEDPVPEA
DEG_COP1_1
0.1111
Drug responses associated with COMMD7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TEDPVPEA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86VX2
COMM domain-containing protein 7
DEG_COP1_1
7:14
TEDPVPEA
COP1
0.8906
More...