DegronMD

Uniprot ID: Q96P66

Source protein: Probable G-protein coupled receptor 101

Source gene: GPR101

Class: DEG_COP1_1

Location: 494:502

E3 ligase: COP1

DEGRON score: 0.5058

ASA_SCORE: 79.8222

COIL: 0.7114

CONS_SCORE: 0.6326

DSS_SCORE: 0.6914

HELIX: 0.0432

FCONS_SCORE: 1.0053

RIG_SCORE: 0.6792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T494S	TCGA-23-1121	OV	TCGA	TEGKIVPSY	DEG_COP1_1	0.6005
p.T494S	DO28731	OV	ICGC	TEGKIVPSY	DEG_COP1_1	0.6005
p.P485R	TCGA-A8-A06P	BRCA	TCGA	TEGKIVPSY	DEG_COP1_1	0.0833
p.P485R	DO5431	BRCA	ICGC	TEGKIVPSY	DEG_COP1_1	0.0833
p.E491D	TCGA-AP-A1E0	UCEC	TCGA	TEGKIVPSY	DEG_COP1_1	0.25
p.E491D	DO43154	UCEC	ICGC	TEGKIVPSY	DEG_COP1_1	0.25
p.G493V	TCGA-AP-A1E1	UCEC	TCGA	TEGKIVPSY	DEG_COP1_1	0.3056
p.G493V	DO43226	UCEC	ICGC	TEGKIVPSY	DEG_COP1_1	0.3056
p.D503N	TCGA-BS-A0UV	UCEC	TCGA	TEGKIVPSY	DEG_COP1_1	0.3056
p.D503N	TCGA-D5-6926	COAD	TCGA	TEGKIVPSY	DEG_COP1_1	0.3056
p.D503N	TCGA-FF-8046	DLBC	TCGA	TEGKIVPSY	DEG_COP1_1	0.3056
p.D503N	DO8530	COAD	ICGC	TEGKIVPSY	DEG_COP1_1	0.3056
p.D503N	DO222303	DLBC	ICGC	TEGKIVPSY	DEG_COP1_1	0.3056
p.D503N	DO42793	UCEC	ICGC	TEGKIVPSY	DEG_COP1_1	0.3056
p.P500H	TCGA-D3-A1Q3	SKCM	TCGA	TEGKIVPSY	DEG_COP1_1	0.7694
p.P500H	DO47509	SKCM	ICGC	TEGKIVPSY	DEG_COP1_1	0.7694
p.D486E	TCGA-EL-A4JX	THCA	TCGA	TEGKIVPSY	DEG_COP1_1	0.1111
p.D486E	DO39892	THCA	ICGC	TEGKIVPSY	DEG_COP1_1	0.1111
p.E495K	TCGA-UC-A7PF	CESC	TCGA	TEGKIVPSY	DEG_COP1_1	0.7022
p.E495K	DO49987	CESC	ICGC	TEGKIVPSY	DEG_COP1_1	0.7022
p.D486V	DO222637	BTCA	ICGC	TEGKIVPSY	DEG_COP1_1	0.1111
p.T494I	DO230311	COCA	ICGC	TEGKIVPSY	DEG_COP1_1	0.7078
p.G489R	DO229493	LAML	ICGC	TEGKIVPSY	DEG_COP1_1	0.1944
p.P508L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	TEGKIVPSY	DEG_COP1_1	0.1667
p.P508L	ACH-000637	Esophageal Cancer	CCLE	TEGKIVPSY	DEG_COP1_1	0.1667
p.P508L	KYSE-520	oesophagus	COSMIC	TEGKIVPSY	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P66	Probable G-protein coupled receptor 101	DEG_COP1_1	494:502	TEGKIVPSY	COP1	0.5058	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons