DegronMD

Uniprot ID: Q86U44

Source protein: N6-adenosine-methyltransferase catalytic subunit

Source gene: METTL3

Class: DEG_COP1_1

Location: 45:55

E3 ligase: COP1

DEGRON score: 0.9945

ASA_SCORE: 89.5182

COIL: 0.9165

CONS_SCORE: 0.3317

DSS_SCORE: 0.7328

HELIX: 0.06

FCONS_SCORE: 1.1074

RIG_SCORE: 0.5826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P53S	TCGA-AA-3815	COAD	TCGA	TFRSDSPVPTA	DEG_COP1_1	0.6752
p.P53S	DO9924	COAD	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.6752
p.A55T	TCGA-EO-A22U	UCEC	TCGA	TFRSDSPVPTA	DEG_COP1_1	0.7139
p.A55T	DO43755	UCEC	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.7139
p.E39K	TCGA-FD-A6TB	BLCA	TCGA	TFRSDSPVPTA	DEG_COP1_1	0.1667
p.E39K	DO51879	BLCA	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.1667
p.T45A	TCGA-G4-6314	COAD	TCGA	TFRSDSPVPTA	DEG_COP1_1	0.7139
p.T45A	DO10381	COAD	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.7139
p.S58F	TCGA-MP-A4T4	LUAD	TCGA	TFRSDSPVPTA	DEG_COP1_1	0.25
p.S58F	DO45357	LUAD	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.25
p.R36W	DO233280	GACA	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.0833
p.R36W	SIDM00074	Burkitt's Lymphoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.0833
p.R36W	SIDM00401	Melanoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.0833
p.R36W	SIDM00202	Ewing's Sarcoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.0833
p.R36W	SIDM00402	Bladder Carcinoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.0833
p.R36W	SIDM00208	Glioblastoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.0833
p.R36W	SIDM01564	Colorectal Carcinoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.0833
p.A55E	DO228974	LICA	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.7701
p.P53H	DO229035	LICA	ICGC	TFRSDSPVPTA	DEG_COP1_1	0.7694
p.R47C	SIDM00496	Thyroid Gland Carcinoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.719
p.R47C	SIDM00242	Osteosarcoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.719
p.R47C	ACH-001350	Thyroid Cancer	CCLE	TFRSDSPVPTA	DEG_COP1_1	0.719
p.R47C	ACH-002042	Thyroid Cancer	CCLE	TFRSDSPVPTA	DEG_COP1_1	0.719
p.R47C	ACH-002067	Bone Cancer	CCLE	TFRSDSPVPTA	DEG_COP1_1	0.719
p.R47C	HTC-C3	thyroid	COSMIC	TFRSDSPVPTA	DEG_COP1_1	0.719
p.R47C	NOS-1	bone	COSMIC	TFRSDSPVPTA	DEG_COP1_1	0.719
p.A41G	SIDM00677	Colorectal Carcinoma	GDSC	TFRSDSPVPTA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86U44	N6-adenosine-methyltransferase catalytic subunit	DEG_COP1_1	45:55	TFRSDSPVPTA	COP1	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TFRSDSPVPTA

Degron related mutations and impact score

Drug responses associated with METTL3 mutations

All proteins holding degron of TFRSDSPVPTA