DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
THLSYKEVPTA
Uniprot ID:
Q96KN1
Source protein:
Protein LRATD2
Source gene:
LRATD2
Class:
DEG_COP1_1
Location:
9:19
E3 ligase:
COP1
DEGRON score:
0.6681
ASA_SCORE:
62.3545
COIL:
0.6043
CONS_SCORE:
0.6537
DSS_SCORE:
0.5665
HELIX:
0.23
FCONS_SCORE:
0.9515
RIG_SCORE:
0.7456
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P21S
SIDM01193
Glioma
GDSC
THLSYKEVPTA
DEG_COP1_1
0.2778
p.G29R
SIDM00145
T-Lymphoblastic Leukemia
GDSC
THLSYKEVPTA
DEG_COP1_1
0.0556
Drug responses associated with LRATD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of THLSYKEVPTA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96KN1
Protein LRATD2
DEG_COP1_1
9:19
THLSYKEVPTA
COP1
0.6681
More...