DegronMD

Uniprot ID: Q5SNV9

Source protein: Uncharacterized protein C1orf167

Source gene: C1orf167

Class: DEG_COP1_1

Location: 178:186

E3 ligase: COP1

DEGRON score: 0.9977

ASA_SCORE: 83.4444

COIL: 0.8411

CONS_SCORE: 0.2363

DSS_SCORE: 0.6101

HELIX: 0.0157

FCONS_SCORE: 1

RIG_SCORE: 0.723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D188N	DO225134	BRCA	ICGC	TKDTPVPEP	DEG_COP1_1	0.2778
p.P182H	DO222817	BTCA	ICGC	TKDTPVPEP	DEG_COP1_1	0.6583
p.P169L	DO233084	GACA	ICGC	TKDTPVPEP	DEG_COP1_1	0.0833
p.R179S	DO229045	LICA	ICGC	TKDTPVPEP	DEG_COP1_1	0.7427
p.G194S	DO220877	MELA	ICGC	TKDTPVPEP	DEG_COP1_1	0.1111
p.D180N	DO220891	MELA	ICGC	TKDTPVPEP	DEG_COP1_1	0.6932
p.KD179KN	DO220891	MELA	ICGC	TKDTPVPEP	DEG_COP1_1	0.6918
p.S194N	SIDM00007	Other Solid Cancers	GDSC	TKDTPVPEP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SNV9	Uncharacterized protein C1orf167	DEG_COP1_1	178:186	TKDTPVPEP	COP1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons