DegronMD

Uniprot ID: Q2M3X9

Source protein: Zinc finger protein 674

Source gene: ZNF674

Class: DEG_APCC_KENBOX_2

Location: 380:384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9771

ASA_SCORE: 84.04

COIL: 0.87

CONS_SCORE: 0.359

DSS_SCORE: 0.3691

HELIX: 0.0222

FCONS_SCORE: 0.8489

RIG_SCORE: 0.7709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K392N	TCGA-AA-A00N	COAD	TCGA	TKENI	DEG_APCC_KENBOX_2	0.2222
p.K392N	DO9876	COAD	ICGC	TKENI	DEG_APCC_KENBOX_2	0.2222
p.R377I	TCGA-AP-A056	UCEC	TCGA	TKENI	DEG_APCC_KENBOX_2	0.25
p.R377I	TCGA-D1-A17Q	UCEC	TCGA	TKENI	DEG_APCC_KENBOX_2	0.25
p.R377I	TCGA-FI-A2D5	UCEC	TCGA	TKENI	DEG_APCC_KENBOX_2	0.25
p.R377I	DO41903	UCEC	ICGC	TKENI	DEG_APCC_KENBOX_2	0.25
p.R377I	DO41331	UCEC	ICGC	TKENI	DEG_APCC_KENBOX_2	0.25
p.R377I	DO43971	UCEC	ICGC	TKENI	DEG_APCC_KENBOX_2	0.25
p.E386Q	TCGA-AP-A0LI	UCEC	TCGA	TKENI	DEG_APCC_KENBOX_2	0.2778
p.E386Q	DO43658	UCEC	ICGC	TKENI	DEG_APCC_KENBOX_2	0.2778
p.H375Q	SIDM00878	Breast Carcinoma	GDSC	TKENI	DEG_APCC_KENBOX_2	0.1944
p.S388G	SIDM00502	B-Lymphoblastic Leukemia	GDSC	TKENI	DEG_APCC_KENBOX_2	0.2222
p.S388G	ACH-000157	Lymphoma	CCLE	TKENI	DEG_APCC_KENBOX_2	0.2222
p.S388G	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	TKENI	DEG_APCC_KENBOX_2	0.2222
p.S382G	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	TKENI	DEG_APCC_KENBOX_2	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M3X9	Zinc finger protein 674	DEG_APCC_KENBOX_2	380:384	TKENI	APC,CDC20,FZR1	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons