DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
TMR
Uniprot ID:
Q86Y46
Source protein:
Keratin, type II cytoskeletal 73
Source gene:
KRT73
Class:
DEG_APCC_TPR_1
Location:
538:540
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6894
ASA_SCORE:
142.5667
COIL:
0.9017
CONS_SCORE:
0.4304
DSS_SCORE:
0.9596
HELIX:
0.0973
FCONS_SCORE:
0.7891
RIG_SCORE:
0.7184
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T538I
TCGA-UY-A9PD
BLCA
TCGA
TMR
DEG_APCC_TPR_1
0.5966
p.T538I
DO219042
BLCA
ICGC
TMR
DEG_APCC_TPR_1
0.5966
Drug responses associated with KRT73 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TMR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86Y46
Keratin, type II cytoskeletal 73
DEG_APCC_TPR_1
538:540
TMR
APC,CDC20,FZR1
0.6894
More...