DegronMD

Uniprot ID: Q8TF45

Source protein: Zinc finger protein 418

Source gene: ZNF418

Class: DEG_SIAH_1

Location: 71:79

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9618

ASA_SCORE: 76.7667

COIL: 0.8019

CONS_SCORE: 0.4229

DSS_SCORE: 0.4581

HELIX: 0.0256

FCONS_SCORE: 1.1573

RIG_SCORE: 0.6203

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E85V	TCGA-61-2095	OV	TCGA	TPGAGVSPK	DEG_SIAH_1	0.1667
p.E85V	DO27987	OV	ICGC	TPGAGVSPK	DEG_SIAH_1	0.1667
p.A89V	TCGA-B5-A11Y	UCEC	TCGA	TPGAGVSPK	DEG_SIAH_1	0.0556
p.A89V	DO40889	UCEC	ICGC	TPGAGVSPK	DEG_SIAH_1	0.0556
p.G88R	TCGA-BH-A0BP	BRCA	TCGA	TPGAGVSPK	DEG_SIAH_1	0.0833
p.G88R	DO4056	BRCA	ICGC	TPGAGVSPK	DEG_SIAH_1	0.0833
p.P78S	TCGA-EB-A41A	SKCM	TCGA	TPGAGVSPK	DEG_SIAH_1	0.6752
p.P78S	DO37429	SKCM	ICGC	TPGAGVSPK	DEG_SIAH_1	0.6752
p.S62F	TCGA-WE-A8ZT	SKCM	TCGA	TPGAGVSPK	DEG_SIAH_1	0.0833
p.S62F	DO51290	SKCM	ICGC	TPGAGVSPK	DEG_SIAH_1	0.0833
p.R80Q	DO9876	COAD	ICGC	TPGAGVSPK	DEG_SIAH_1	0.3056
p.R71H	DO234437	ESAD	ICGC	TPGAGVSPK	DEG_SIAH_1	0.8244
p.S62Y	DO233195	GACA	ICGC	TPGAGVSPK	DEG_SIAH_1	0.0833
p.S77C	DO224581	LUSC	ICGC	TPGAGVSPK	DEG_SIAH_1	0.7541
p.S83Y	DO232826	NACA	ICGC	TPGAGVSPK	DEG_SIAH_1	0.2222
p.S77F	DO38404	STAD	ICGC	TPGAGVSPK	DEG_SIAH_1	0.7982
p.I62M	SIDM00656	Burkitt's Lymphoma	GDSC	TPGAGVSPK	DEG_SIAH_1	0.0833
p.I62M	SIDM00641	Burkitt's Lymphoma	GDSC	TPGAGVSPK	DEG_SIAH_1	0.0833
p.S64C	SIDM01435	Hepatocellular Carcinoma	GDSC	TPGAGVSPK	DEG_SIAH_1	0.1389
p.A89T	ACH-000995	Leukemia	CCLE	TPGAGVSPK	DEG_SIAH_1	0.0556
p.A89T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TPGAGVSPK	DEG_SIAH_1	0.0556
p.V69A	ACH-000999	Colon/Colorectal Cancer	CCLE	TPGAGVSPK	DEG_SIAH_1	0.2778
p.V69A	SNU-1040	large_intestine	COSMIC	TPGAGVSPK	DEG_SIAH_1	0.2778
p.S74P	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	TPGAGVSPK	DEG_SIAH_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF45	Zinc finger protein 418	DEG_SIAH_1	71:79	TPGAGVSPK	SIAH1,SIAH2,SIAH3	0.9618	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons