DegronMD

Uniprot ID: B7Z6K7

Source protein: Zinc finger protein 814

Source gene: ZNF814

Class: DEG_SIAH_1

Location: 81:89

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.6283

ASA_SCORE: 82.2222

COIL: 0.7747

CONS_SCORE: 0.2813

DSS_SCORE: 0.4709

HELIX: 0.0274

FCONS_SCORE: 0.8676

RIG_SCORE: 0.6822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P99L	TCGA-CK-5913	COAD	TCGA	TPMAGVSPK	DEG_SIAH_1	0.0556
p.P99L	DO8826	COAD	ICGC	TPMAGVSPK	DEG_SIAH_1	0.0556
p.N93K	DO234169	ESAD	ICGC	TPMAGVSPK	DEG_SIAH_1	0.2222
p.A84T	DO50980	LAML	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A84T	DO51035	LAML	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A84T	DO51039	LAML	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A84T	DO52374	LUSC	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A84T	DO52365	LUSC	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A84T	DO52361	LUSC	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A84T	DO52381	LUSC	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A84T	DO229121	THCA	ICGC	TPMAGVSPK	DEG_SIAH_1	0.7139
p.A86V	DO223282	UCEC	ICGC	TPMAGVSPK	DEG_SIAH_1	0.6936
p.A91T	DO42673	UCEC	ICGC	TPMAGVSPK	DEG_SIAH_1	0.2778
p.M83I	ACH-000548	Head and Neck Cancer	CCLE	TPMAGVSPK	DEG_SIAH_1	0.6507
p.G85R	A431	skin	COSMIC	TPMAGVSPK	DEG_SIAH_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B7Z6K7	Zinc finger protein 814	DEG_SIAH_1	81:89	TPMAGVSPK	SIAH1,SIAH2,SIAH3	0.6283	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons