DegronMD

Uniprot ID: P02751

Source protein: Fibronectin

Source gene: FN1

Class: DEG_COP1_1

Location: 901:910

E3 ligase: COP1

DEGRON score: 0.8223

ASA_SCORE: 73.97

COIL: 0.824

CONS_SCORE: 0.4109

DSS_SCORE: 0.6137

HELIX: 0.02

FCONS_SCORE: 0.8157

RIG_SCORE: 0.6878

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D920Y	TCGA-AP-A056	UCEC	TCGA	TPRSDTVPSP	DEG_COP1_1	0.0556
p.D920Y	DO43971	UCEC	ICGC	TPRSDTVPSP	DEG_COP1_1	0.0556
p.T898A	TCGA-CA-6717	COAD	TCGA	TPRSDTVPSP	DEG_COP1_1	0.25
p.T898A	DO8264	COAD	ICGC	TPRSDTVPSP	DEG_COP1_1	0.25
p.S909F	TCGA-EE-A29E	SKCM	TCGA	TPRSDTVPSP	DEG_COP1_1	0.7982
p.S909F	DO37831	SKCM	ICGC	TPRSDTVPSP	DEG_COP1_1	0.7982
p.R903C	TCGA-IB-7645	PAAD	TCGA	TPRSDTVPSP	DEG_COP1_1	0.719
p.R903C	DO46629	PAAD	ICGC	TPRSDTVPSP	DEG_COP1_1	0.719
p.D920E	DO229035	LICA	ICGC	TPRSDTVPSP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02751	Fibronectin	DEG_COP1_1	901:910	TPRSDTVPSP	COP1	0.8223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons