DegronMD

Uniprot ID: Q9UD57

Source protein: NK1 transcription factor-related protein 2

Source gene: NKX1-2

Class: DEG_APCC_DBOX_1

Location: 32:40

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5735

ASA_SCORE: 89.0444

COIL: 0.8278

CONS_SCORE: 0.1911

DSS_SCORE: 0.4533

HELIX: 0.138

FCONS_SCORE: 0.4226

RIG_SCORE: 0.7655

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R33C	ACH-000985	Colon/Colorectal Cancer	CCLE	TRAALPAVR	DEG_APCC_DBOX_1	0.8301
p.V39E	DO48889	PBCA	ICGC	TRAALPAVR	DEG_APCC_DBOX_1	0.7693
p.L36I	DO234441	ESAD	ICGC	TRAALPAVR	DEG_APCC_DBOX_1	0.7174
p.F31L	DO228978	LICA	ICGC	TRAALPAVR	DEG_APCC_DBOX_1	0.3056
p.Q29H	TCGA-A5-A2K5	UCEC	TCGA	TRAALPAVR	DEG_APCC_DBOX_1	0.25
p.Q29H	DO41379	UCEC	ICGC	TRAALPAVR	DEG_APCC_DBOX_1	0.25
p.D27H	DO229016	COCA	ICGC	TRAALPAVR	DEG_APCC_DBOX_1	0.1944
p.D24Y	TCGA-AP-A059	UCEC	TCGA	TRAALPAVR	DEG_APCC_DBOX_1	0.1111
p.D24Y	DO41361	UCEC	ICGC	TRAALPAVR	DEG_APCC_DBOX_1	0.1111

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UD57	NK1 transcription factor-related protein 2	DEG_APCC_DBOX_1	32:40	TRAALPAVR	APC,CDC20,FZR1	0.5735	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons