DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TRAALPAVR
Uniprot ID:
Q9UD57
Source protein:
NK1 transcription factor-related protein 2
Source gene:
NKX1-2
Class:
DEG_APCC_DBOX_1
Location:
32:40
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5735
ASA_SCORE:
89.0444
COIL:
0.8278
CONS_SCORE:
0.1911
DSS_SCORE:
0.4533
HELIX:
0.138
FCONS_SCORE:
0.4226
RIG_SCORE:
0.7655
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q29H
TCGA-A5-A2K5
UCEC
TCGA
TRAALPAVR
DEG_APCC_DBOX_1
0.25
p.Q29H
DO41379
UCEC
ICGC
TRAALPAVR
DEG_APCC_DBOX_1
0.25
p.D24Y
TCGA-AP-A059
UCEC
TCGA
TRAALPAVR
DEG_APCC_DBOX_1
0.1111
p.D24Y
DO41361
UCEC
ICGC
TRAALPAVR
DEG_APCC_DBOX_1
0.1111
p.D27H
DO229016
COCA
ICGC
TRAALPAVR
DEG_APCC_DBOX_1
0.1944
p.L36I
DO234441
ESAD
ICGC
TRAALPAVR
DEG_APCC_DBOX_1
0.7174
p.F31L
DO228978
LICA
ICGC
TRAALPAVR
DEG_APCC_DBOX_1
0.3056
p.V39E
DO48889
PBCA
ICGC
TRAALPAVR
DEG_APCC_DBOX_1
0.7693
p.R33C
ACH-000985
Colon/Colorectal Cancer
CCLE
TRAALPAVR
DEG_APCC_DBOX_1
0.8301
Drug responses associated with NKX1-2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRAALPAVR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UD57
NK1 transcription factor-related protein 2
DEG_APCC_DBOX_1
32:40
TRAALPAVR
APC,CDC20,FZR1
0.5735
More...