DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
TRGQLHVLR
Uniprot ID:
B0FP48
Source protein:
Uroplakin-3b-like protein 1
Source gene:
UPK3BL1
Class:
DEG_APCC_DBOX_1
Location:
129:137
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.744
ASA_SCORE:
58.8556
COIL:
0.5041
CONS_SCORE:
0.6108
DSS_SCORE:
0.2858
HELIX:
0.0239
FCONS_SCORE:
0.853
RIG_SCORE:
0.8128
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with UPK3BL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRGQLHVLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
B0FP48
Uroplakin-3b-like protein 1
DEG_APCC_DBOX_1
129:137
TRGQLHVLR
APC,CDC20,FZR1
0.744
More...
E5RIL1
Uroplakin-3b-like protein 2
DEG_APCC_DBOX_1
129:137
TRGQLHVLR
APC,CDC20,FZR1
0.744
More...