DegronMD

Uniprot ID: O94874

Source protein: E3 UFM1-protein ligase 1

Source gene: UFL1

Class: DEG_APCC_DBOX_1

Location: 768:776

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9787

ASA_SCORE: 73.1889

COIL: 0.1077

CONS_SCORE: 0.4428

DSS_SCORE: 0.4558

HELIX: 0.893

FCONS_SCORE: 1.5502

RIG_SCORE: 0.7567

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T767N	TCGA-19-5956	GBM	TCGA	TRKELQELS	DEG_APCC_DBOX_1	0.3056
p.T767N	DO13863	GBM	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.3056
p.R769H	TCGA-AX-A05S	UCEC	TCGA	TRKELQELS	DEG_APCC_DBOX_1	0.8244
p.R769H	DO43218	UCEC	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.8244
p.R769H	SIDM02035	Colorectal Carcinoma	GDSC	TRKELQELS	DEG_APCC_DBOX_1	0.8244
p.R769H	ACH-001356	Thyroid Cancer	CCLE	TRKELQELS	DEG_APCC_DBOX_1	0.8244
p.L784I	TCGA-AX-A05Z	UCEC	TCGA	TRKELQELS	DEG_APCC_DBOX_1	0.1111
p.L784I	DO40884	UCEC	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.1111
p.A765T	TCGA-DF-A2KU	UCEC	TCGA	TRKELQELS	DEG_APCC_DBOX_1	0.25
p.A765T	DO223286	UCEC	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.25
p.S778F	TCGA-EE-A2MS	SKCM	TCGA	TRKELQELS	DEG_APCC_DBOX_1	0.7222
p.S778F	DO37567	SKCM	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.7222
p.A765S	TCGA-QS-A5YQ	UCEC	TCGA	TRKELQELS	DEG_APCC_DBOX_1	0.25
p.A765S	DO49073	UCEC	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.25
p.S777L	DO222498	MELA	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.75
p.E762K	DO222653	MELA	ICGC	TRKELQELS	DEG_APCC_DBOX_1	0.1667
p.D781V	SIDM00789	Colorectal Carcinoma	GDSC	TRKELQELS	DEG_APCC_DBOX_1	0.1944
p.D781V	ACH-000997	Colon/Colorectal Cancer	CCLE	TRKELQELS	DEG_APCC_DBOX_1	0.1944
p.D781V	ACH-001061	Colon/Colorectal Cancer	CCLE	TRKELQELS	DEG_APCC_DBOX_1	0.1944
p.D781V	HCT-15	large_intestine	COSMIC	TRKELQELS	DEG_APCC_DBOX_1	0.1944
p.T768S	SIDM00633	Breast Carcinoma	GDSC	TRKELQELS	DEG_APCC_DBOX_1	0.6005
p.T768S	ACH-000759	Breast Cancer	CCLE	TRKELQELS	DEG_APCC_DBOX_1	0.6005
p.T768S	MDA-MB-175-VII	breast	COSMIC	TRKELQELS	DEG_APCC_DBOX_1	0.6005
p.E760K	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	TRKELQELS	DEG_APCC_DBOX_1	0.1111
p.E760K	ACH-000672	Lung Cancer	CCLE	TRKELQELS	DEG_APCC_DBOX_1	0.1111
p.E760K	IA-LM	lung	COSMIC	TRKELQELS	DEG_APCC_DBOX_1	0.1111
p.E771A	ACH-001577	Leukemia	CCLE	TRKELQELS	DEG_APCC_DBOX_1	0.659

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRKELQELS

Degron related mutations and impact score

Drug responses associated with UFL1 mutations

All proteins holding degron of TRKELQELS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94874	E3 UFM1-protein ligase 1	DEG_APCC_DBOX_1	768:776	TRKELQELS	APC,CDC20,FZR1	0.9787	More...