DegronMD

Uniprot ID: Q63HM1

Source protein: Kynurenine formamidase

Source gene: AFMID

Class: DEG_APCC_DBOX_1

Location: 59:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7923

ASA_SCORE: 73.0111

COIL: 0.7494

CONS_SCORE: 0.4639

DSS_SCORE: 0.3784

HELIX: 0.1058

FCONS_SCORE: 1.0062

RIG_SCORE: 0.7644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G49R	TCGA-AX-A06F	UCEC	TCGA	TRKSLLHVP	DEG_APCC_DBOX_1	0.0556
p.Y68C	TCGA-KS-A41F	THCA	TCGA	TRKSLLHVP	DEG_APCC_DBOX_1	0.3056
p.Y68C	DO40423	THCA	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.3056
p.E55K	DO51933	BLCA	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.2222
p.I64L	DO225283	BRCA	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.7174
p.I64L	DO227940	BRCA	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.7174
p.V57L	DO229008	LICA	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.2778
p.T70M	DO45326	LUAD	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.25
p.S62R	DO50688	ORCA	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.6316
p.R54I	DO50076	UCEC	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.R54I	DO52412	UCEC	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.R54I	DO43755	UCEC	ICGC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.E72K	SIDM00570	Gastric Carcinoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.E72K	SIDM00530	Esophageal Carcinoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.E72K	SIDM00282	Colorectal Carcinoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.E72K	SIDM00687	Gastric Carcinoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.E72K	SIDM00618	Hepatocellular Carcinoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.E72K	SIDM00989	Bladder Carcinoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.E72K	SIDM01727	Chronic Myelogenous Leukemia	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.1944
p.G71S	SIDM01051	Ovarian Carcinoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.2222
p.G71S	SIDM00867	Glioblastoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.2222
p.R57W	SIDM00621	Ewing's Sarcoma	GDSC	TRKSLLHVP	DEG_APCC_DBOX_1	0.2778
p.R57W	ACH-002113	Bone Cancer	CCLE	TRKSLLHVP	DEG_APCC_DBOX_1	0.2778
p.R57W	EW-13	bone	COSMIC	TRKSLLHVP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63HM1	Kynurenine formamidase	DEG_APCC_DBOX_1	59:67	TRKSLLHVP	APC,CDC20,FZR1	0.7923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons