DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
TRQPLPRIV
Uniprot ID:
Q9P202
Source protein:
Whirlin
Source gene:
WHRN
Class:
DEG_APCC_DBOX_1
Location:
836:844
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9065
ASA_SCORE:
71.1333
COIL:
0.6482
CONS_SCORE:
0.7892
DSS_SCORE:
0.39
HELIX:
0.0083
FCONS_SCORE:
1.1335
RIG_SCORE:
0.8057
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A829T
SIDM00980
Gastric Carcinoma
GDSC
TRQPLPRIV
DEG_APCC_DBOX_1
0.1389
p.A829T
23132-87
stomach
COSMIC
TRQPLPRIV
DEG_APCC_DBOX_1
0.1389
Drug responses associated with WHRN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRQPLPRIV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P202
Whirlin
DEG_APCC_DBOX_1
836:844
TRQPLPRIV
APC,CDC20,FZR1
0.9065
More...