DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
TRTKLQHLD
Uniprot ID:
B7ZC32
Source protein:
Kinesin-like protein KIF28P
Source gene:
KIF28P
Class:
DEG_APCC_DBOX_1
Location:
459:467
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8643
ASA_SCORE:
70.1444
COIL:
0.4854
CONS_SCORE:
0.451
DSS_SCORE:
0.2042
HELIX:
0.0057
FCONS_SCORE:
0.8589
RIG_SCORE:
0.9035
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with KIF28P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TRTKLQHLD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
B7ZC32
Kinesin-like protein KIF28P
DEG_APCC_DBOX_1
459:467
TRTKLQHLD
APC,CDC20,FZR1
0.8643
More...