DegronMD

Uniprot ID: Q6VMQ6

Source protein: Activating transcription factor 7-interacting protein 1

Source gene: ATF7IP

Class: DEG_APCC_DBOX_1

Location: 885:893

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.764

ASA_SCORE: 88.1444

COIL: 0.8651

CONS_SCORE: 0.572

DSS_SCORE: 0.459

HELIX: 0.0403

FCONS_SCORE: 1.0867

RIG_SCORE: 0.7153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P876S	TCGA-56-5897	LUSC	TCGA	TRTSLPTVG	DEG_APCC_DBOX_1	0.0833
p.R886M	TCGA-AN-A0AK	BRCA	TCGA	TRTSLPTVG	DEG_APCC_DBOX_1	0.8632
p.V892A	TCGA-CG-5721	STAD	TCGA	TRTSLPTVG	DEG_APCC_DBOX_1	0.6936
p.S888F	TCGA-EA-A3QE	CESC	TCGA	TRTSLPTVG	DEG_APCC_DBOX_1	0.6871
p.P876Q	TCGA-EE-A29E	SKCM	TCGA	TRTSLPTVG	DEG_APCC_DBOX_1	0.0833
p.R885M	DO1608	BRCA	ICGC	TRTSLPTVG	DEG_APCC_DBOX_1	0.8632
p.S887F	DO49019	CESC	ICGC	TRTSLPTVG	DEG_APCC_DBOX_1	0.7982
p.P875S	DO26453	LUSC	ICGC	TRTSLPTVG	DEG_APCC_DBOX_1	0.0556
p.P875Q	DO37831	SKCM	ICGC	TRTSLPTVG	DEG_APCC_DBOX_1	0.0556
p.V891A	DO38192	STAD	ICGC	TRTSLPTVG	DEG_APCC_DBOX_1	0.6936
p.R903Q	DO42793	UCEC	ICGC	TRTSLPTVG	DEG_APCC_DBOX_1	0.0556
p.P902T	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	TRTSLPTVG	DEG_APCC_DBOX_1	0.0833
p.P902T	NCI-H1623	lung	COSMIC	TRTSLPTVG	DEG_APCC_DBOX_1	0.0833
p.P894T	ACH-000744	Lung Cancer	CCLE	TRTSLPTVG	DEG_APCC_DBOX_1	0.3056
p.P894T	NCI-H1623	lung	COSMIC	TRTSLPTVG	DEG_APCC_DBOX_1	0.3056
p.T877I	ACH-002055	Lymphoma	CCLE	TRTSLPTVG	DEG_APCC_DBOX_1	0.1111
p.P893T	NCI-H1623	lung	COSMIC	TRTSLPTVG	DEG_APCC_DBOX_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_APCC_DBOX_1	885:893	TRTSLPTVG	APC,CDC20,FZR1	0.764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons