DegronMD

Uniprot ID: Q5T2W1

Source protein: Na

Source gene: PDZK1

Class: DEG_APCC_DBOX_1

Location: 98:106

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.875

ASA_SCORE: 86.5889

COIL: 0.6293

CONS_SCORE: 0.6064

DSS_SCORE: 0.4084

HELIX: 0.3441

FCONS_SCORE: 1.2622

RIG_SCORE: 0.8256

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K97N	TCGA-B5-A1MR	UCEC	TCGA	TRVDLKELG	DEG_APCC_DBOX_1	0.3056
p.K97N	DO41758	UCEC	ICGC	TRVDLKELG	DEG_APCC_DBOX_1	0.3056
p.G106R	TCGA-BH-A6R9	BRCA	TCGA	TRVDLKELG	DEG_APCC_DBOX_1	0.6457
p.G106R	DO219611	BRCA	ICGC	TRVDLKELG	DEG_APCC_DBOX_1	0.6457
p.E93D	TCGA-EO-A3AY	UCEC	TCGA	TRVDLKELG	DEG_APCC_DBOX_1	0.1944
p.E93D	DO43202	UCEC	ICGC	TRVDLKELG	DEG_APCC_DBOX_1	0.1944
p.D88Y	ACH-000496	Lung Cancer	CCLE	TRVDLKELG	DEG_APCC_DBOX_1	0.0556
p.D88Y	NCI-H1792	lung	COSMIC	TRVDLKELG	DEG_APCC_DBOX_1	0.0556
p.G106A	ACH-000705	Lung Cancer	CCLE	TRVDLKELG	DEG_APCC_DBOX_1	0.6429
p.G106A	ACH-001113	Lung Cancer	CCLE	TRVDLKELG	DEG_APCC_DBOX_1	0.6429
p.G106A	LC-1-sq	lung	COSMIC	TRVDLKELG	DEG_APCC_DBOX_1	0.6429
p.R99Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	TRVDLKELG	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T2W1	Na	DEG_APCC_DBOX_1	98:106	TRVDLKELG	APC,CDC20,FZR1	0.875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons