DegronMD

Uniprot ID: Q9HCM3

Source protein: UPF0606 protein KIAA1549

Source gene: KIAA1549

Class: DEG_COP1_1

Location: 238:246

E3 ligase: COP1

DEGRON score: 0.9977

ASA_SCORE: 81.5333

COIL: 0.8577

CONS_SCORE: 0.3172

DSS_SCORE: 0.3473

HELIX: 0.0149

FCONS_SCORE: 1.0838

RIG_SCORE: 0.7121

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V243L	TCGA-49-4506	LUAD	TCGA	TSEGIVPTP	DEG_COP1_1	0.6765
p.V243L	DO25084	LUAD	ICGC	TSEGIVPTP	DEG_COP1_1	0.6765
p.R237C	TCGA-AD-5900	COAD	TCGA	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237C	TCGA-EY-A215	UCEC	TCGA	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237C	TCGA-F7-A624	HNSC	TCGA	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237C	DO52641	BOCA	ICGC	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237C	DO8514	COAD	ICGC	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237C	DO44440	HNSC	ICGC	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237C	DO42665	UCEC	ICGC	TSEGIVPTP	DEG_COP1_1	0.3056
p.R233W	TCGA-AG-A002	READ	TCGA	TSEGIVPTP	DEG_COP1_1	0.1944
p.R233W	TCGA-BB-A6UO	HNSC	TCGA	TSEGIVPTP	DEG_COP1_1	0.1944
p.R233W	TCGA-BR-8382	STAD	TCGA	TSEGIVPTP	DEG_COP1_1	0.1944
p.R233W	TCGA-EE-A3J5	SKCM	TCGA	TSEGIVPTP	DEG_COP1_1	0.1944
p.R233W	DO218985	HNSC	ICGC	TSEGIVPTP	DEG_COP1_1	0.1944
p.R233W	DO47331	SKCM	ICGC	TSEGIVPTP	DEG_COP1_1	0.1944
p.R233W	DO47925	STAD	ICGC	TSEGIVPTP	DEG_COP1_1	0.1944
p.P254S	TCGA-D3-A51F	SKCM	TCGA	TSEGIVPTP	DEG_COP1_1	0.1111
p.P254S	DO47503	SKCM	ICGC	TSEGIVPTP	DEG_COP1_1	0.1111
p.P254S	SIDM00284	Melanoma	GDSC	TSEGIVPTP	DEG_COP1_1	0.1111
p.P254S	ACH-000805	Skin Cancer	CCLE	TSEGIVPTP	DEG_COP1_1	0.1111
p.P254S	COLO-679	skin	COSMIC	TSEGIVPTP	DEG_COP1_1	0.1111
p.G247D	TCGA-IB-7651	PAAD	TCGA	TSEGIVPTP	DEG_COP1_1	0.3056
p.G247D	DO46657	PAAD	ICGC	TSEGIVPTP	DEG_COP1_1	0.3056
p.Y253F	TCGA-LK-A4O5	MESO	TCGA	TSEGIVPTP	DEG_COP1_1	0.1389
p.P244S	DO220872	MELA	ICGC	TSEGIVPTP	DEG_COP1_1	0.6752
p.R237H	SIDM02059	Colorectal Carcinoma	GDSC	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237H	SIDM00217	Colorectal Carcinoma	GDSC	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237H	ACH-000999	Colon/Colorectal Cancer	CCLE	TSEGIVPTP	DEG_COP1_1	0.3056
p.R237H	SNU-1040	large_intestine	COSMIC	TSEGIVPTP	DEG_COP1_1	0.3056
p.T231I	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	TSEGIVPTP	DEG_COP1_1	0.1389
p.P246S	ACH-002396	Bone Cancer	CCLE	TSEGIVPTP	DEG_COP1_1	0.6752
p.P246S	Sarc9371	bone	COSMIC	TSEGIVPTP	DEG_COP1_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSEGIVPTP

Degron related mutations and impact score

Drug responses associated with KIAA1549 mutations

All proteins holding degron of TSEGIVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM3	UPF0606 protein KIAA1549	DEG_COP1_1	238:246	TSEGIVPTP	COP1	0.9977	More...