DegronMD

Uniprot ID: Q96CW5

Source protein: Gamma-tubulin complex component 3

Source gene: TUBGCP3

Class: DEG_COP1_1

Location: 217:225

E3 ligase: COP1

DEGRON score: 0.9822

ASA_SCORE: 70.8556

COIL: 0.8733

CONS_SCORE: 0.2118

DSS_SCORE: 0.649

HELIX: 0.0977

FCONS_SCORE: 0.8741

RIG_SCORE: 0.6487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T218A	TCGA-05-5425	LUAD	TCGA	TTSKGVPSA	DEG_COP1_1	0.6028
p.T218A	DO26270	LUAD	ICGC	TTSKGVPSA	DEG_COP1_1	0.6028
p.T208I	TCGA-2W-A8YY	CESC	TCGA	TTSKGVPSA	DEG_COP1_1	0.0833
p.T208I	DO223732	CESC	ICGC	TTSKGVPSA	DEG_COP1_1	0.0833
p.R228H	TCGA-EO-A22R	UCEC	TCGA	TTSKGVPSA	DEG_COP1_1	0.25
p.R228H	DO42713	UCEC	ICGC	TTSKGVPSA	DEG_COP1_1	0.25
p.R235G	DO225249	BRCA	ICGC	TTSKGVPSA	DEG_COP1_1	0.0556
p.S227C	DO228102	EOPC	ICGC	TTSKGVPSA	DEG_COP1_1	0.2778
p.N229S	DO232048	ORCA	ICGC	TTSKGVPSA	DEG_COP1_1	0.2222
p.T231A	DO233524	PRAD	ICGC	TTSKGVPSA	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CW5	Gamma-tubulin complex component 3	DEG_COP1_1	217:225	TTSKGVPSA	COP1	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons