DegronMD

Uniprot ID: O60245

Source protein: Protocadherin-7

Source gene: PCDH7

Class: DEG_SCF_FBW7_2

Location: 248:255

E3 ligase: FBXW7

DEGRON score: 0.7339

ASA_SCORE: 69.1

COIL: 0.6186

CONS_SCORE: 0.5591

DSS_SCORE: 0.6328

HELIX: 0.0068

FCONS_SCORE: 0.8918

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G264R	DO222862	BTCA	ICGC	VADTPDGE	DEG_SCF_FBW7_2	0.0833
p.A265V	DO38663	STAD	ICGC	VADTPDGE	DEG_SCF_FBW7_2	0.0556
p.A265V	SIDM02021	Esophageal Carcinoma	GDSC	VADTPDGE	DEG_SCF_FBW7_2	0.0556
p.A265V	ACH-000937	Leukemia	CCLE	VADTPDGE	DEG_SCF_FBW7_2	0.0556
p.A249V	SIDM01943	Colorectal Carcinoma	GDSC	VADTPDGE	DEG_SCF_FBW7_2	0.5825
p.S242T	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VADTPDGE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60245	Protocadherin-7	DEG_SCF_FBW7_2	248:255	VADTPDGE	FBXW7	0.7339	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons