DegronMD

Uniprot ID: P11021

Source protein: Endoplasmic reticulum chaperone BiP

Source gene: HSPA5

Class: DEG_SCF_FBW7_2

Location: 66:73

E3 ligase: FBXW7

DEGRON score: 0.9327

ASA_SCORE: 45.7

COIL: 0.4134

CONS_SCORE: 0.6933

DSS_SCORE: 0.3743

HELIX: 0.006

FCONS_SCORE: 0.8398

RIG_SCORE: 0.7871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E71K	TCGA-AC-A2B8	BRCA	TCGA	VAFTPEGE	DEG_SCF_FBW7_2	0.591
p.E71K	DO5884	BRCA	ICGC	VAFTPEGE	DEG_SCF_FBW7_2	0.591
p.P70T	TCGA-DD-A4NP	LIHC	TCGA	VAFTPEGE	DEG_SCF_FBW7_2	0.7031
p.P70T	DO44958	LIHC	ICGC	VAFTPEGE	DEG_SCF_FBW7_2	0.7031
p.G72V	TCGA-EE-A2GH	SKCM	TCGA	VAFTPEGE	DEG_SCF_FBW7_2	0.6421
p.G72V	DO37643	SKCM	ICGC	VAFTPEGE	DEG_SCF_FBW7_2	0.6421
p.T69P	ACH-000354	Pancreatic Cancer	CCLE	VAFTPEGE	DEG_SCF_FBW7_2	0.8142
p.T69P	CAPAN-1	pancreas	COSMIC	VAFTPEGE	DEG_SCF_FBW7_2	0.8142
p.A67T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VAFTPEGE	DEG_SCF_FBW7_2	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11021	Endoplasmic reticulum chaperone BiP	DEG_SCF_FBW7_2	66:73	VAFTPEGE	FBXW7	0.9327	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons