DegronMD

Uniprot ID: Q8IYF1

Source protein: Elongin-A2

Source gene: ELOA2

Class: DEG_SCF_FBW7_1

Location: 647:654

E3 ligase: FBXW7

DEGRON score: 0.6544

ASA_SCORE: 83.225

COIL: 0.8306

CONS_SCORE: 0.6169

DSS_SCORE: 0.5425

HELIX: 0.1049

FCONS_SCORE: 1.2313

RIG_SCORE: 0.7166

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T650M	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VAKTPYDT	DEG_SCF_FBW7_1	0.7423
p.E659G	SIDM00496	Thyroid Gland Carcinoma	GDSC	VAKTPYDT	DEG_SCF_FBW7_1	0.1944
p.E659G	HTC-C3	thyroid	COSMIC	VAKTPYDT	DEG_SCF_FBW7_1	0.1944
p.E638D	SIDM01564	Colorectal Carcinoma	GDSC	VAKTPYDT	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYF1	Elongin-A2	DEG_SCF_FBW7_1	647:654	VAKTPYDT	FBXW7	0.6544	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons