DegronMD

Uniprot ID: P02751

Source protein: Fibronectin

Source gene: FN1

Class: LIG_APCC_ABBA_1

Location: 1794:1799

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.706

ASA_SCORE: 52.8

COIL: 0.3747

CONS_SCORE: 0.4368

DSS_SCORE: 0.4571

HELIX: 0.0032

FCONS_SCORE: 0.9041

RIG_SCORE: 0.7901

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1797Y	TCGA-AP-A059	UCEC	TCGA	VALHDD	LIG_APCC_ABBA_1	0.6118
p.H1797Y	DO41361	UCEC	ICGC	VALHDD	LIG_APCC_ABBA_1	0.6118
p.Y1789H	TCGA-BT-A3PK	BLCA	TCGA	VALHDD	LIG_APCC_ABBA_1	0.1944
p.G1807R	TCGA-ER-A19H	SKCM	TCGA	VALHDD	LIG_APCC_ABBA_1	0.1111
p.G1807R	DO47299	SKCM	ICGC	VALHDD	LIG_APCC_ABBA_1	0.1111
p.E1801G	TCGA-F4-6704	COAD	TCGA	VALHDD	LIG_APCC_ABBA_1	0.2778
p.D1798N	TCGA-FI-A2D6	UCEC	TCGA	VALHDD	LIG_APCC_ABBA_1	0.5821
p.A1809T	DO219024	BLCA	ICGC	VALHDD	LIG_APCC_ABBA_1	0.0556
p.A1809T	DO51629	CESC	ICGC	VALHDD	LIG_APCC_ABBA_1	0.0556
p.A1809T	DO8192	COAD	ICGC	VALHDD	LIG_APCC_ABBA_1	0.0556
p.R1801Q	DO233941	GACA	ICGC	VALHDD	LIG_APCC_ABBA_1	0.2778
p.K1790N	DO13863	GBM	ICGC	VALHDD	LIG_APCC_ABBA_1	0.2222
p.V1792I	DO228264	LICA	ICGC	VALHDD	LIG_APCC_ABBA_1	0.2778
p.A1785T	DO47769	STAD	ICGC	VALHDD	LIG_APCC_ABBA_1	0.0833
p.Q1809H	DO229253	THCA	ICGC	VALHDD	LIG_APCC_ABBA_1	0.0556
p.Q1803R	SIDM01274	Esophageal Carcinoma	GDSC	VALHDD	LIG_APCC_ABBA_1	0.2222
p.H1797Q	SIDM00128	Head and Neck Carcinoma	GDSC	VALHDD	LIG_APCC_ABBA_1	0.7582
p.H1797Q	ACH-002249	Head and Neck Cancer	CCLE	VALHDD	LIG_APCC_ABBA_1	0.7582
p.H1797Q	JHU-011	upper_aerodigestive_tract	COSMIC	VALHDD	LIG_APCC_ABBA_1	0.7582
p.T1808I	SIDM01519	Head and Neck Carcinoma	GDSC	VALHDD	LIG_APCC_ABBA_1	0.0833
p.T1808I	ACH-000786	Lymphoma	CCLE	VALHDD	LIG_APCC_ABBA_1	0.0833
p.T1808I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VALHDD	LIG_APCC_ABBA_1	0.0833
p.V1807D	ACH-000920	Leukemia	CCLE	VALHDD	LIG_APCC_ABBA_1	0.1111
p.V1807D	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VALHDD	LIG_APCC_ABBA_1	0.1111
p.V1808D	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VALHDD	LIG_APCC_ABBA_1	0.0833
p.P1785A	RF-48	stomach	COSMIC	VALHDD	LIG_APCC_ABBA_1	0.0833
p.R1801W	SNU-81	large_intestine	COSMIC	VALHDD	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VALHDD

Degron related mutations and impact score

Drug responses associated with FN1 mutations

All proteins holding degron of VALHDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02751	Fibronectin	LIG_APCC_ABBA_1	1794:1799	VALHDD	APC,CDC20,FZR1	0.706	More...