DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_SCF_FBW7_2

Location: 1128:1135

E3 ligase: FBXW7

DEGRON score: 0.9461

ASA_SCORE: 111.9875

COIL: 0.9498

CONS_SCORE: 0.3358

DSS_SCORE: 0.4843

HELIX: 0.0226

FCONS_SCORE: 0.863

RIG_SCORE: 0.7071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1142T	TCGA-BT-A3PJ	BLCA	TCGA	VAQTPLHE	DEG_SCF_FBW7_2	0.1389
p.P1142T	DO44097	BLCA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.1389
p.P1141S	TCGA-CN-A63U	HNSC	TCGA	VAQTPLHE	DEG_SCF_FBW7_2	0.1667
p.P1141S	DO44454	HNSC	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.1667
p.E1119K	TCGA-DK-AA6Q	BLCA	TCGA	VAQTPLHE	DEG_SCF_FBW7_2	0.0833
p.E1119K	DO219005	BLCA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.0833
p.S1144F	TCGA-FW-A3R5	SKCM	TCGA	VAQTPLHE	DEG_SCF_FBW7_2	0.0833
p.S1144F	DO37406	SKCM	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.0833
p.Q1130H	TCGA-VS-A9UM	CESC	TCGA	VAQTPLHE	DEG_SCF_FBW7_2	0.647
p.Q1130H	DO51644	CESC	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.647
p.V1128I	DO222760	COCA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.5965
p.Q1130E	DO228357	LICA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.5633
p.P1137Q	DO228948	LICA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.2778
p.P1127T	DO228974	LICA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.3056
p.P1127T	DO229019	LICA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.3056
p.H1126N	DO229037	LICA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.2778
p.P1137S	DO35242	PACA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.2778
p.T1131R	DO234133	THCA	ICGC	VAQTPLHE	DEG_SCF_FBW7_2	0.7876
p.P1141L	SIDM01146	Gastric Carcinoma	GDSC	VAQTPLHE	DEG_SCF_FBW7_2	0.1667
p.P1141L	ACH-000932	Gastric Cancer	CCLE	VAQTPLHE	DEG_SCF_FBW7_2	0.1667
p.P1141L	NCI-SNU-1	stomach	COSMIC	VAQTPLHE	DEG_SCF_FBW7_2	0.1667
p.V1128F	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	VAQTPLHE	DEG_SCF_FBW7_2	0.7068
p.V1128F	ACH-002221	Lymphoma	CCLE	VAQTPLHE	DEG_SCF_FBW7_2	0.7068
p.V1128F	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VAQTPLHE	DEG_SCF_FBW7_2	0.7068
p.A1129S	ACH-000596	Lung Cancer	CCLE	VAQTPLHE	DEG_SCF_FBW7_2	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	DEG_SCF_FBW7_2	1128:1135	VAQTPLHE	FBXW7	0.9461	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VAQTPLHE

Degron related mutations and impact score

Drug responses associated with HIVEP3 mutations

All proteins holding degron of VAQTPLHE