DegronMD

Uniprot ID: P82912

Source protein: 28S ribosomal protein S11, mitochondrial

Source gene: MRPS11

Class: DEG_SCF_FBW7_1

Location: 25:32

E3 ligase: FBXW7

DEGRON score: 0.9948

ASA_SCORE: 64.6

COIL: 0.7431

CONS_SCORE: 0.3019

DSS_SCORE: 0.3943

HELIX: 0.0801

FCONS_SCORE: 0.9868

RIG_SCORE: 0.7762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q41P	TCGA-61-2012	OV	TCGA	VARTPAGT	DEG_SCF_FBW7_1	0.0833
p.Q41P	DO32536	OV	ICGC	VARTPAGT	DEG_SCF_FBW7_1	0.0833
p.R23W	TCGA-99-8032	LUAD	TCGA	VARTPAGT	DEG_SCF_FBW7_1	0.2778
p.R23W	DO23765	LUAD	ICGC	VARTPAGT	DEG_SCF_FBW7_1	0.2778
p.W17C	DO229038	LICA	ICGC	VARTPAGT	DEG_SCF_FBW7_1	0.1111
p.G22C	DO229041	LICA	ICGC	VARTPAGT	DEG_SCF_FBW7_1	0.25
p.Q39H	SIDM00789	Colorectal Carcinoma	GDSC	VARTPAGT	DEG_SCF_FBW7_1	0.1389
p.Q39H	ACH-000997	Colon/Colorectal Cancer	CCLE	VARTPAGT	DEG_SCF_FBW7_1	0.1389
p.Q39H	HCT-15	large_intestine	COSMIC	VARTPAGT	DEG_SCF_FBW7_1	0.1389
p.T16A	ACH-000961	Endometrial/Uterine Cancer	CCLE	VARTPAGT	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P82912	28S ribosomal protein S11, mitochondrial	DEG_SCF_FBW7_1	25:32	VARTPAGT	FBXW7	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons