DegronMD

Uniprot ID: P19532

Source protein: Transcription factor E3

Source gene: TFE3

Class: DEG_SCF_FBW7_1

Location: 311:317

E3 ligase: FBXW7

DEGRON score: 0.9477

ASA_SCORE: 69.5286

COIL: 0.826

CONS_SCORE: 0.6476

DSS_SCORE: 0.3094

HELIX: 0.0327

FCONS_SCORE: 0.9883

RIG_SCORE: 0.7591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S321F	TCGA-17-Z026	LUAD	TCGA	VATPAIT	DEG_SCF_FBW7_1	0.6667
p.V311M	TCGA-AJ-A3BH	UCEC	TCGA	VATPAIT	DEG_SCF_FBW7_1	0.6097
p.V311M	DO41638	UCEC	ICGC	VATPAIT	DEG_SCF_FBW7_1	0.6097
p.L302V	DO1076	BRCA	ICGC	VATPAIT	DEG_SCF_FBW7_1	0.0833
p.L302M	DO229028	LICA	ICGC	VATPAIT	DEG_SCF_FBW7_1	0.0833
p.G310D	DO232224	PBCA	ICGC	VATPAIT	DEG_SCF_FBW7_1	0.3056
p.S308N	SIDM00720	Mesothelioma	GDSC	VATPAIT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19532	Transcription factor E3	DEG_SCF_FBW7_1	311:317	VATPAIT	FBXW7	0.9477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons