DegronMD

Uniprot ID: Q01167

Source protein: Forkhead box protein K2

Source gene: FOXK2

Class: DEG_SCF_FBW7_1

Location: 454:460

E3 ligase: FBXW7

DEGRON score: 0.9482

ASA_SCORE: 91.6571

COIL: 0.9629

CONS_SCORE: 0.3929

DSS_SCORE: 0.3397

HELIX: 0.0139

FCONS_SCORE: 0.981

RIG_SCORE: 0.7769

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P449H	DO46591	OV	ICGC	VATPVTT	DEG_SCF_FBW7_1	0.1944
p.A446S	TCGA-55-7911	LUAD	TCGA	VATPVTT	DEG_SCF_FBW7_1	0.1111
p.A446S	DO24821	LUAD	ICGC	VATPVTT	DEG_SCF_FBW7_1	0.1111
p.Q445L	DO3182	BRCA	ICGC	VATPVTT	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01167	Forkhead box protein K2	DEG_SCF_FBW7_1	454:460	VATPVTT	FBXW7	0.9482	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons