DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VATPVTT
Uniprot ID:
Q01167
Source protein:
Forkhead box protein K2
Source gene:
FOXK2
Class:
DEG_SCF_FBW7_1
Location:
454:460
E3 ligase:
FBXW7
DEGRON score:
0.9482
ASA_SCORE:
91.6571
COIL:
0.9629
CONS_SCORE:
0.3929
DSS_SCORE:
0.3397
HELIX:
0.0139
FCONS_SCORE:
0.981
RIG_SCORE:
0.7769
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A446S
TCGA-55-7911
LUAD
TCGA
VATPVTT
DEG_SCF_FBW7_1
0.1111
p.A446S
DO24821
LUAD
ICGC
VATPVTT
DEG_SCF_FBW7_1
0.1111
p.Q445L
DO3182
BRCA
ICGC
VATPVTT
DEG_SCF_FBW7_1
0.0833
p.P449H
DO46591
OV
ICGC
VATPVTT
DEG_SCF_FBW7_1
0.1944
Drug responses associated with FOXK2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VATPVTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q01167
Forkhead box protein K2
DEG_SCF_FBW7_1
454:460
VATPVTT
FBXW7
0.9482
More...