DegronMD

Uniprot ID: Q8TEY7

Source protein: Ubiquitin carboxyl-terminal hydrolase 33

Source gene: USP33

Class: LIG_APCC_ABBA_1

Location: 163:168

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5245

ASA_SCORE: 82.1167

COIL: 0.6967

CONS_SCORE: 0.2627

DSS_SCORE: 0.304

HELIX: 0.2098

FCONS_SCORE: 0.8542

RIG_SCORE: 0.8855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E176D	TCGA-96-8169	LUSC	TCGA	VAVFDD	LIG_APCC_ABBA_1	0.1111
p.V165I	TCGA-A5-A1OF	UCEC	TCGA	VAVFDD	LIG_APCC_ABBA_1	0.5965
p.V165I	TCGA-IB-7651	PAAD	TCGA	VAVFDD	LIG_APCC_ABBA_1	0.5965
p.N155D	TCGA-AA-3852	COAD	TCGA	VAVFDD	LIG_APCC_ABBA_1	0.1111
p.P161H	TCGA-B5-A1MX	UCEC	TCGA	VAVFDD	LIG_APCC_ABBA_1	0.2778
p.P176T	DO228900	LICA	ICGC	VAVFDD	LIG_APCC_ABBA_1	0.1111
p.P177H	DO228976	LICA	ICGC	VAVFDD	LIG_APCC_ABBA_1	0.0833
p.N166K	DO50859	LIRI	ICGC	VAVFDD	LIG_APCC_ABBA_1	0.6918
p.G160V	DO29378	OV	ICGC	VAVFDD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEY7	Ubiquitin carboxyl-terminal hydrolase 33	LIG_APCC_ABBA_1	163:168	VAVFDD	APC,CDC20,FZR1	0.5245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons