DegronMD

Uniprot ID: Q92499

Source protein: ATP-dependent RNA helicase DDX1

Source gene: DDX1

Class: LIG_APCC_ABBA_1

Location: 543:548

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.763

ASA_SCORE: 35.9167

COIL: 0.518

CONS_SCORE: 0.7196

DSS_SCORE: 0.3241

HELIX: 0.0485

FCONS_SCORE: 1.3118

RIG_SCORE: 0.7574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H546D	TCGA-97-A4M5	LUAD	TCGA	VCLHGD	LIG_APCC_ABBA_1	0.7688
p.H546D	DO218938	LUAD	ICGC	VCLHGD	LIG_APCC_ABBA_1	0.7688
p.H546N	TCGA-A5-A2K5	UCEC	TCGA	VCLHGD	LIG_APCC_ABBA_1	0.7423
p.H546N	TCGA-B5-A1MR	UCEC	TCGA	VCLHGD	LIG_APCC_ABBA_1	0.7423
p.H546N	DO41758	UCEC	ICGC	VCLHGD	LIG_APCC_ABBA_1	0.7423
p.H546N	DO41379	UCEC	ICGC	VCLHGD	LIG_APCC_ABBA_1	0.7423
p.R554T	DO233876	GACA	ICGC	VCLHGD	LIG_APCC_ABBA_1	0.1667
p.K535T	SIDM01682	Gastric Carcinoma	GDSC	VCLHGD	LIG_APCC_ABBA_1	0.5556
p.K535T	ACH-000110	Gastric Cancer	CCLE	VCLHGD	LIG_APCC_ABBA_1	0.5556
p.C557Y	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	VCLHGD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92499	ATP-dependent RNA helicase DDX1	LIG_APCC_ABBA_1	543:548	VCLHGD	APC,CDC20,FZR1	0.763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons