DegronMD

Uniprot ID: Q9NQC3

Source protein: Reticulon-4

Source gene: RTN4

Class: LIG_APCC_ABBA_1

Location: 745:750

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.632

ASA_SCORE: 81.4833

COIL: 0.8283

CONS_SCORE: 0.671

DSS_SCORE: 0.7404

HELIX: 0.1323

FCONS_SCORE: 0.9754

RIG_SCORE: 0.6892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P757L	TCGA-42-2590	OV	TCGA	VDLFSD	LIG_APCC_ABBA_1	0.1389
p.P740S	TCGA-DU-6407	LGG	TCGA	VDLFSD	LIG_APCC_ABBA_1	0.1944
p.S751Y	DO3572	BRCA	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.3056
p.D752N	DO8898	COAD	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.2778
p.D752N	DO229056	LICA	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.2778
p.D752N	DO42033	UCEC	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.2778
p.D748V	DO223039	ESCA	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.7785
p.E757D	DO10880	GBM	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.1389
p.T754N	DO229031	LICA	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.2222
p.S760R	DO229041	LICA	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.0556
p.S760N	DO46657	PAAD	ICGC	VDLFSD	LIG_APCC_ABBA_1	0.0556
p.P754H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VDLFSD	LIG_APCC_ABBA_1	0.2222
p.P754H	ACH-002256	Leukemia	CCLE	VDLFSD	LIG_APCC_ABBA_1	0.2222
p.P754H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VDLFSD	LIG_APCC_ABBA_1	0.2222
p.V756I	ACH-001061	Colon/Colorectal Cancer	CCLE	VDLFSD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQC3	Reticulon-4	LIG_APCC_ABBA_1	745:750	VDLFSD	APC,CDC20,FZR1	0.632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons