DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VDTPSGT
Uniprot ID:
P62877
Source protein:
E3 ubiquitin-protein ligase RBX1
Source gene:
RBX1
Class:
DEG_SCF_FBW7_1
Location:
7:13
E3 ligase:
FBXW7
DEGRON score:
0.9542
ASA_SCORE:
84.5857
COIL:
0.9623
CONS_SCORE:
0.3395
DSS_SCORE:
0.5332
HELIX:
0.0279
FCONS_SCORE:
0.8158
RIG_SCORE:
0.6904
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A3T
TCGA-RY-A83Z
LGG
TCGA
VDTPSGT
DEG_SCF_FBW7_1
0.6667
p.A3T
DO219839
LGG
ICGC
VDTPSGT
DEG_SCF_FBW7_1
0.6667
p.M5V
DO228342
LICA
ICGC
VDTPSGT
DEG_SCF_FBW7_1
0.7222
p.G12V
DO228986
LICA
ICGC
VDTPSGT
DEG_SCF_FBW7_1
0.6421
p.S15I
DO224563
LUSC
ICGC
VDTPSGT
DEG_SCF_FBW7_1
0.7222
p.A3E
SIDM00789
Colorectal Carcinoma
GDSC
VDTPSGT
DEG_SCF_FBW7_1
0.6667
p.A3E
ACH-000997
Colon/Colorectal Cancer
CCLE
VDTPSGT
DEG_SCF_FBW7_1
0.6667
p.A3E
ACH-001061
Colon/Colorectal Cancer
CCLE
VDTPSGT
DEG_SCF_FBW7_1
0.6667
p.A3E
HCT-15
large_intestine
COSMIC
VDTPSGT
DEG_SCF_FBW7_1
0.6667
p.D6G
SIDM01154
T-Lymphoblastic Leukemia
GDSC
VDTPSGT
DEG_SCF_FBW7_1
0.4167
p.D6G
ACH-000953
Leukemia
CCLE
VDTPSGT
DEG_SCF_FBW7_1
0.4167
p.D6G
SUP-T1
haematopoietic_and_lymphoid_tissue
COSMIC
VDTPSGT
DEG_SCF_FBW7_1
0.4167
p.T13S
SIDM00749
Non-Small Cell Lung Carcinoma
GDSC
VDTPSGT
DEG_SCF_FBW7_1
0.7116
p.T13S
ACH-000916
Lung Cancer
CCLE
VDTPSGT
DEG_SCF_FBW7_1
0.7116
p.A3S
ACH-000944
Lymphoma
CCLE
VDTPSGT
DEG_SCF_FBW7_1
0.6667
p.A3V
ACH-001701
Head and Neck Cancer
CCLE
VDTPSGT
DEG_SCF_FBW7_1
0.6667
Drug responses associated with RBX1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VDTPSGT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P62877
E3 ubiquitin-protein ligase RBX1
DEG_SCF_FBW7_1
7:13
VDTPSGT
FBXW7
0.9542
More...