DegronMD

Uniprot ID: P17022

Source protein: Zinc finger protein 18

Source gene: ZNF18

Class: LIG_APCC_ABBA_1

Location: 154:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9275

ASA_SCORE: 92.1167

COIL: 0.7413

CONS_SCORE: 0.6736

DSS_SCORE: 0.5214

HELIX: 0.1703

FCONS_SCORE: 1.1106

RIG_SCORE: 0.7506

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L158F	ACH-001211	Rhabdoid	CCLE	VEPHLE	LIG_APCC_ABBA_1	0.587
p.S148I	TCGA-AP-A0LM	UCEC	TCGA	VEPHLE	LIG_APCC_ABBA_1	0.1667
p.S148I	DO43306	UCEC	ICGC	VEPHLE	LIG_APCC_ABBA_1	0.1667
p.P147A	TCGA-AA-3989	COAD	TCGA	VEPHLE	LIG_APCC_ABBA_1	0.1389
p.P147A	DO9666	COAD	ICGC	VEPHLE	LIG_APCC_ABBA_1	0.1389

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17022	Zinc finger protein 18	LIG_APCC_ABBA_1	154:159	VEPHLE	APC,CDC20,FZR1	0.9275	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons