DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VFPYFD
Uniprot ID:
Q8IZF2
Source protein:
Adhesion G protein-coupled receptor F5
Source gene:
ADGRF5
Class:
LIG_APCC_ABBA_1
Location:
871:876
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7013
ASA_SCORE:
65.2667
COIL:
0.5722
CONS_SCORE:
0.2543
DSS_SCORE:
0.0418
HELIX:
0.0492
FCONS_SCORE:
0.6795
RIG_SCORE:
0.9501
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V882L
SIDM00334
Endometrial Carcinoma
GDSC
VFPYFD
LIG_APCC_ABBA_1
0.1667
p.V882L
MFE-296
endometrium
COSMIC
VFPYFD
LIG_APCC_ABBA_1
0.1667
Drug responses associated with ADGRF5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VFPYFD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IZF2
Adhesion G protein-coupled receptor F5
LIG_APCC_ABBA_1
871:876
VFPYFD
APC,CDC20,FZR1
0.7013
More...