DegronMD

Uniprot ID: Q8TCG2

Source protein: Phosphatidylinositol 4-kinase type 2-beta

Source gene: PI4K2B

Class: LIG_APCC_ABBA_1

Location: 119:124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 47.4167

COIL: 0.7953

CONS_SCORE: 0.5508

DSS_SCORE: 0.3164

HELIX: 0.0572

FCONS_SCORE: 0.8835

RIG_SCORE: 0.8369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A125V	DO22237	LGG	ICGC	VGIFPE	LIG_APCC_ABBA_1	0.3056
p.A125V	DO42673	UCEC	ICGC	VGIFPE	LIG_APCC_ABBA_1	0.3056
p.I126T	ACH-002017	Eye Cancer	CCLE	VGIFPE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCG2	Phosphatidylinositol 4-kinase type 2-beta	LIG_APCC_ABBA_1	119:124	VGIFPE	APC,CDC20,FZR1	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons