DegronMD

Uniprot ID: O15553

Source protein: Pyrin

Source gene: MEFV

Class: LIG_APCC_ABBA_1

Location: 718:723

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7077

ASA_SCORE: 8.2667

COIL: 0.0383

CONS_SCORE: 0.586

DSS_SCORE: 0.0818

HELIX: 0.002

FCONS_SCORE: 1.3116

RIG_SCORE: 0.8992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G719V	TCGA-A8-A07U	BRCA	TCGA	VGIFVD	LIG_APCC_ABBA_1	0.6421
p.G727A	TCGA-DK-A1AC	BLCA	TCGA	VGIFVD	LIG_APCC_ABBA_1	0.2222
p.S730F	TCGA-FW-A3R5	SKCM	TCGA	VGIFVD	LIG_APCC_ABBA_1	0.1389
p.D723N	TCGA-GF-A3OT	SKCM	TCGA	VGIFVD	LIG_APCC_ABBA_1	0.6932
p.R708C	SIDM00461	Acute Myeloid Leukemia	GDSC	VGIFVD	LIG_APCC_ABBA_1	0.0556
p.R708C	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VGIFVD	LIG_APCC_ABBA_1	0.0556
p.V726A	SIDM01120	Other Solid Cancers	GDSC	VGIFVD	LIG_APCC_ABBA_1	0.25
p.V726A	SIDM00941	Kidney Carcinoma	GDSC	VGIFVD	LIG_APCC_ABBA_1	0.25
p.V726A	SIDM00140	Melanoma	GDSC	VGIFVD	LIG_APCC_ABBA_1	0.25
p.F721Y	SIDM00893	Breast Carcinoma	GDSC	VGIFVD	LIG_APCC_ABBA_1	0.6417
p.F721Y	BT-20	breast	COSMIC	VGIFVD	LIG_APCC_ABBA_1	0.6417
p.D723E	ACH-000681	Lung Cancer	CCLE	VGIFVD	LIG_APCC_ABBA_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15553	Pyrin	LIG_APCC_ABBA_1	718:723	VGIFVD	APC,CDC20,FZR1	0.7077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons