DegronMD

Uniprot ID: Q9Y314

Source protein: Nitric oxide synthase-interacting protein

Source gene: NOSIP

Class: DEG_SCF_FBW7_1

Location: 200:207

E3 ligase: FBXW7

DEGRON score: 0.8905

ASA_SCORE: 62.95

COIL: 0.5086

CONS_SCORE: 0.4752

DSS_SCORE: 0.3129

HELIX: 0.026

FCONS_SCORE: 1.0932

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R217C	TCGA-A5-A1OF	UCEC	TCGA	VHFTPLDS	DEG_SCF_FBW7_1	0.0556
p.V200A	TCGA-AG-3731	READ	TCGA	VHFTPLDS	DEG_SCF_FBW7_1	0.6936
p.G213V	TCGA-AP-A0LS	UCEC	TCGA	VHFTPLDS	DEG_SCF_FBW7_1	0.1667
p.T198M	TCGA-CG-4442	STAD	TCGA	VHFTPLDS	DEG_SCF_FBW7_1	0.7222
p.T198M	DO38380	STAD	ICGC	VHFTPLDS	DEG_SCF_FBW7_1	0.7222
p.T216A	TCGA-VQ-A8PP	STAD	TCGA	VHFTPLDS	DEG_SCF_FBW7_1	0.5278
p.V203A	DO36463	READ	ICGC	VHFTPLDS	DEG_SCF_FBW7_1	0.6936
p.G216V	DO43178	UCEC	ICGC	VHFTPLDS	DEG_SCF_FBW7_1	0.5278
p.R193C	ACH-000953	Leukemia	CCLE	VHFTPLDS	DEG_SCF_FBW7_1	0.1389
p.R217H	ACH-000997	Colon/Colorectal Cancer	CCLE	VHFTPLDS	DEG_SCF_FBW7_1	0.0556
p.R217H	ACH-001061	Colon/Colorectal Cancer	CCLE	VHFTPLDS	DEG_SCF_FBW7_1	0.0556
p.R217H	HCT-15	large_intestine	COSMIC	VHFTPLDS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y314	Nitric oxide synthase-interacting protein	DEG_SCF_FBW7_1	200:207	VHFTPLDS	FBXW7	0.8905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons