DegronMD

Uniprot ID: O15266

Source protein: Short stature homeobox protein

Source gene: SHOX

Class: LIG_APCC_ABBA_1

Location: 68:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5439

ASA_SCORE: 114.4667

COIL: 0.7537

CONS_SCORE: 0.3334

DSS_SCORE: 0.4443

HELIX: 0.2327

FCONS_SCORE: 0.8176

RIG_SCORE: 0.7919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V68E	TCGA-05-5420	LUAD	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.7693
p.V68E	DO26005	LUAD	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.7693
p.D58H	TCGA-55-7815	LUAD	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.0556
p.D58H	DO24537	LUAD	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.0556
p.K72M	TCGA-55-8207	LUAD	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.6951
p.K72M	DO45351	LUAD	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.6951
p.H69N	TCGA-56-8305	LUSC	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.6312
p.H69N	DO223725	LUSC	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.6312
p.G63C	TCGA-78-7155	LUAD	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.1944
p.G63C	DO23590	LUAD	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.1944
p.H74R	TCGA-A6-5665	COAD	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.3056
p.H74R	DO9756	COAD	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.3056
p.G64S	TCGA-AG-3592	READ	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.2222
p.G64S	DO37308	READ	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.2222
p.P67Q	TCGA-AP-A0LE	UCEC	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.3056
p.P67Q	DO43418	UCEC	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.3056
p.V68A	TCGA-AX-A2HJ	UCEC	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.6936
p.V68A	DO42105	UCEC	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.6936
p.H69Q	TCGA-DA-A1HY	SKCM	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.647
p.H69Q	DO37409	SKCM	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.647
p.G64R	TCGA-E7-A519	BLCA	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.2222
p.G64R	DO44028	BLCA	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.2222
p.E80D	TCGA-EO-A22X	UCEC	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.1389
p.E80D	DO43907	UCEC	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.1389
p.H65L	TCGA-G9-6351	PRAD	TCGA	VHLFKD	LIG_APCC_ABBA_1	0.25
p.H65L	DO36325	PRAD	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.25
p.D73Y	DO228986	LICA	ICGC	VHLFKD	LIG_APCC_ABBA_1	0.7325
p.V75I	SIDM01314	Colorectal Carcinoma	GDSC	VHLFKD	LIG_APCC_ABBA_1	0.2778
p.D76E	SIDM01413	Oral Cavity Carcinoma	GDSC	VHLFKD	LIG_APCC_ABBA_1	0.25
p.I59S	ACH-002287	Colon/Colorectal Cancer	CCLE	VHLFKD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15266	Short stature homeobox protein	LIG_APCC_ABBA_1	68:73	VHLFKD	APC,CDC20,FZR1	0.5439	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VHLFKD

Degron related mutations and impact score

Drug responses associated with SHOX mutations

All proteins holding degron of VHLFKD