DegronMD

Uniprot ID: Q8TEQ6

Source protein: Gem-associated protein 5

Source gene: GEMIN5

Class: DEG_SCF_FBW7_1

Location: 804:811

E3 ligase: FBXW7

DEGRON score: 0.5974

ASA_SCORE: 60.825

COIL: 0.5096

CONS_SCORE: 0.4825

DSS_SCORE: 0.3664

HELIX: 0.0186

FCONS_SCORE: 1.0042

RIG_SCORE: 0.7516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S810F	TCGA-A5-A2K5	UCEC	TCGA	VICTPVSS	DEG_SCF_FBW7_1	0.6871
p.S810F	DO41379	UCEC	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.6871
p.E814Q	TCGA-AO-A0JC	BRCA	TCGA	VICTPVSS	DEG_SCF_FBW7_1	0.25
p.E814Q	DO5277	BRCA	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.25
p.A798V	TCGA-AP-A0LM	UCEC	TCGA	VICTPVSS	DEG_SCF_FBW7_1	0.1667
p.A798V	TCGA-DK-AA77	BLCA	TCGA	VICTPVSS	DEG_SCF_FBW7_1	0.1667
p.A798V	DO219014	BLCA	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.1667
p.A798V	DO43306	UCEC	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.1667
p.C806Y	TCGA-AX-A1CE	UCEC	TCGA	VICTPVSS	DEG_SCF_FBW7_1	0.5976
p.C806Y	DO42280	UCEC	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.5976
p.I820V	TCGA-BH-A0B4	BRCA	TCGA	VICTPVSS	DEG_SCF_FBW7_1	0.0833
p.I820V	DO4617	BRCA	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.0833
p.R801K	TCGA-VS-A9UC	CESC	TCGA	VICTPVSS	DEG_SCF_FBW7_1	0.25
p.R801K	DO219732	CESC	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.25
p.I820F	DO228278	LICA	ICGC	VICTPVSS	DEG_SCF_FBW7_1	0.0833
p.L795R	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VICTPVSS	DEG_SCF_FBW7_1	0.0833
p.L795R	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VICTPVSS	DEG_SCF_FBW7_1	0.0833
p.L795R	ACH-000519	Leukemia	CCLE	VICTPVSS	DEG_SCF_FBW7_1	0.0833
p.L795R	ACH-002216	Leukemia	CCLE	VICTPVSS	DEG_SCF_FBW7_1	0.0833
p.L795R	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	VICTPVSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEQ6	Gem-associated protein 5	DEG_SCF_FBW7_1	804:811	VICTPVSS	FBXW7	0.5974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons