DegronMD

Uniprot ID: O60260

Source protein: E3 ubiquitin-protein ligase parkin

Source gene: PRKN

Class: LIG_APCC_ABBA_1

Location: 121:126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9305

ASA_SCORE: 66.8667

COIL: 0.4503

CONS_SCORE: 0.1427

DSS_SCORE: 0.4687

HELIX: 0.065

FCONS_SCORE: 1.0935

RIG_SCORE: 0.7983

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A134V	SIDM02015	Colorectal Carcinoma	GDSC	VILHTD	LIG_APCC_ABBA_1	0.1111
p.P113T	SIDM00090	Ovarian Carcinoma	GDSC	VILHTD	LIG_APCC_ABBA_1	0.1111
p.P113T	OVCAR-8	ovary	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.1111
p.A120V	SIDM01106	Melanoma	GDSC	VILHTD	LIG_APCC_ABBA_1	0.3056
p.A120V	SK-MEL-24	skin	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.3056
p.D126E	SIDM01387	Small Cell Lung Carcinoma	GDSC	VILHTD	LIG_APCC_ABBA_1	0.5647
p.E119G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.2778
p.R123W	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.8634
p.I133V	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.1389
p.A117T	MEL-JUSO	skin	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.2222
p.C119S	NCI-H1781	lung	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.2778
p.R126Q	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.7329
p.R131C	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.6389
p.R131H	HCT-15	large_intestine	COSMIC	VILHTD	LIG_APCC_ABBA_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60260	E3 ubiquitin-protein ligase parkin	LIG_APCC_ABBA_1	121:126	VILHTD	APC,CDC20,FZR1	0.9305	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons