DegronMD

Uniprot ID: Q9NQC7

Source protein: Ubiquitin carboxyl-terminal hydrolase CYLD

Source gene: CYLD

Class: DEG_APCC_KENBOX_2

Location: 478:482

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7719

ASA_SCORE: 75.42

COIL: 0.6352

CONS_SCORE: 0.4916

DSS_SCORE: 0.2488

HELIX: 0.0088

FCONS_SCORE: 0.7765

RIG_SCORE: 0.7357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P482L	TCGA-BF-A5EQ	SKCM	TCGA	VKENP	DEG_APCC_KENBOX_2	0.6471
p.P482L	DO219452	SKCM	ICGC	VKENP	DEG_APCC_KENBOX_2	0.6471
p.G492S	TCGA-BR-8078	STAD	TCGA	VKENP	DEG_APCC_KENBOX_2	0.0556
p.G492S	DO38288	STAD	ICGC	VKENP	DEG_APCC_KENBOX_2	0.0556
p.E471D	TCGA-CD-8529	STAD	TCGA	VKENP	DEG_APCC_KENBOX_2	0.1389
p.E471D	DO47753	STAD	ICGC	VKENP	DEG_APCC_KENBOX_2	0.1389
p.P483H	TCGA-DA-A1IB	SKCM	TCGA	VKENP	DEG_APCC_KENBOX_2	0.3056
p.P483H	DO38033	SKCM	ICGC	VKENP	DEG_APCC_KENBOX_2	0.3056
p.A476V	TCGA-DU-6392	LGG	TCGA	VKENP	DEG_APCC_KENBOX_2	0.2778
p.A476V	DO22237	LGG	ICGC	VKENP	DEG_APCC_KENBOX_2	0.2778
p.E471Q	TCGA-EA-A3HU	CESC	TCGA	VKENP	DEG_APCC_KENBOX_2	0.1389
p.E471Q	DO6320	CESC	ICGC	VKENP	DEG_APCC_KENBOX_2	0.1389
p.E480K	TCGA-EB-A4IS	SKCM	TCGA	VKENP	DEG_APCC_KENBOX_2	0.7022
p.E480K	DO47281	SKCM	ICGC	VKENP	DEG_APCC_KENBOX_2	0.7022
p.H468P	TCGA-EO-A22R	UCEC	TCGA	VKENP	DEG_APCC_KENBOX_2	0.0556
p.H468P	DO42713	UCEC	ICGC	VKENP	DEG_APCC_KENBOX_2	0.0556
p.L475V	DO233893	GACA	ICGC	VKENP	DEG_APCC_KENBOX_2	0.25
p.V472A	DO233865	GACA	ICGC	VKENP	DEG_APCC_KENBOX_2	0.1667
p.W490C	DO229045	LICA	ICGC	VKENP	DEG_APCC_KENBOX_2	0.1111
p.P483L	DO229479	SKCA	ICGC	VKENP	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQC7	Ubiquitin carboxyl-terminal hydrolase CYLD	DEG_APCC_KENBOX_2	478:482	VKENP	APC,CDC20,FZR1	0.7719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons