DegronMD

Uniprot ID: Q00059

Source protein: Transcription factor A, mitochondrial

Source gene: TFAM

Class: DEG_APCC_KENBOX_2

Location: 185:189

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9153

ASA_SCORE: 51.98

COIL: 0.0326

CONS_SCORE: 0.3949

DSS_SCORE: 0.4887

HELIX: 0.9684

FCONS_SCORE: 1.0127

RIG_SCORE: 0.7823

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S185Y	DO13863	GBM	ICGC	VKENW	DEG_APCC_KENBOX_2	0.712
p.R195Q	DO229054	LICA	ICGC	VKENW	DEG_APCC_KENBOX_2	0.6111
p.R178C	DO220906	MELA	ICGC	VKENW	DEG_APCC_KENBOX_2	0.1389
p.R178H	DO35442	PACA	ICGC	VKENW	DEG_APCC_KENBOX_2	0.1389
p.D175N	DO37818	SKCM	ICGC	VKENW	DEG_APCC_KENBOX_2	0.0556
p.M190I	DO41903	UCEC	ICGC	VKENW	DEG_APCC_KENBOX_2	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00059	Transcription factor A, mitochondrial	DEG_APCC_KENBOX_2	185:189	VKENW	APC,CDC20,FZR1	0.9153	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons