DegronMD

Uniprot ID: P07197

Source protein: Neurofilament medium polypeptide

Source gene: NEFM

Class: LIG_APCC_ABBA_1

Location: 753:758

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9881

ASA_SCORE: 115.0667

COIL: 0.8453

CONS_SCORE: 0.7578

DSS_SCORE: 0.4833

HELIX: 0.1143

FCONS_SCORE: 1.0192

RIG_SCORE: 0.7903

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S752L	TCGA-BS-A0UV	UCEC	TCGA	VKVHLE	LIG_APCC_ABBA_1	0.3056
p.S752L	DO42793	UCEC	ICGC	VKVHLE	LIG_APCC_ABBA_1	0.3056
p.A744T	TCGA-EO-A22R	UCEC	TCGA	VKVHLE	LIG_APCC_ABBA_1	0.0833
p.A744T	DO42713	UCEC	ICGC	VKVHLE	LIG_APCC_ABBA_1	0.0833
p.V747F	DO228974	LICA	ICGC	VKVHLE	LIG_APCC_ABBA_1	0.1667
p.G752C	RKO	large_intestine	COSMIC	VKVHLE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07197	Neurofilament medium polypeptide	LIG_APCC_ABBA_1	753:758	VKVHLE	APC,CDC20,FZR1	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons