DegronMD

Uniprot ID: P02786

Source protein: Transferrin receptor protein 1

Source gene: TFRC

Class: LIG_APCC_ABBA_1

Location: 279:284

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6395

ASA_SCORE: 9.9333

COIL: 0.3795

CONS_SCORE: 0.5822

DSS_SCORE: 0.0275

HELIX: 0.0102

FCONS_SCORE: 1.2389

RIG_SCORE: 0.9549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E294K	TCGA-BT-A20Q	BLCA	TCGA	VLIYMD	LIG_APCC_ABBA_1	0.0556
p.E294K	DO695	BLCA	ICGC	VLIYMD	LIG_APCC_ABBA_1	0.0556
p.Y282S	DO1203	BRCA	ICGC	VLIYMD	LIG_APCC_ABBA_1	0.8231
p.P289L	SIDM01483	Melanoma	GDSC	VLIYMD	LIG_APCC_ABBA_1	0.1944
p.P289L	ACH-000582	Skin Cancer	CCLE	VLIYMD	LIG_APCC_ABBA_1	0.1944
p.P289L	COLO-741	large_intestine	COSMIC	VLIYMD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02786	Transferrin receptor protein 1	LIG_APCC_ABBA_1	279:284	VLIYMD	APC,CDC20,FZR1	0.6395	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons