DegronMD

Uniprot ID: P12081

Source protein: Histidine--tRNA ligase, cytoplasmic

Source gene: HARS1

Class: DEG_SCF_FBW7_1

Location: 55:62

E3 ligase: FBXW7

DEGRON score: 0.9592

ASA_SCORE: 56.75

COIL: 0.882

CONS_SCORE: 0.5578

DSS_SCORE: 0.4751

HELIX: 0.0165

FCONS_SCORE: 1.412

RIG_SCORE: 0.739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S66T	SIDM00735	Small Cell Lung Carcinoma	GDSC	VLKTPKGT	DEG_SCF_FBW7_1	0.6667
p.M70I	SIDM00988	Kidney Carcinoma	GDSC	VLKTPKGT	DEG_SCF_FBW7_1	0.1111
p.F54C	SIDM01611	Endometrial Carcinoma	GDSC	VLKTPKGT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12081	Histidine--tRNA ligase, cytoplasmic	DEG_SCF_FBW7_1	55:62	VLKTPKGT	FBXW7	0.9592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons