DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VLLYDE
Uniprot ID:
Q16829
Source protein:
Dual specificity protein phosphatase 7
Source gene:
DUSP7
Class:
LIG_APCC_ABBA_1
Location:
133:138
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7269
ASA_SCORE:
19.1167
COIL:
0.3007
CONS_SCORE:
0.4354
DSS_SCORE:
0.216
HELIX:
0.0117
FCONS_SCORE:
1.3755
RIG_SCORE:
0.867
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S143F
DO51275
SKCM
ICGC
VLLYDE
LIG_APCC_ABBA_1
0.1944
p.W143L
DO229259
THCA
ICGC
VLLYDE
LIG_APCC_ABBA_1
0.1944
p.G123S
DO220881
MELA
ICGC
VLLYDE
LIG_APCC_ABBA_1
0.0556
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Drug responses associated with DUSP7 mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VLLYDE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16829
Dual specificity protein phosphatase 7
LIG_APCC_ABBA_1
133:138
VLLYDE
APC,CDC20,FZR1
0.7269
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