DegronMD

Uniprot ID: Q8N960

Source protein: Centrosomal protein of 120 kDa

Source gene: CEP120

Class: DEG_SCF_FBW7_2

Location: 366:372

E3 ligase: FBXW7

DEGRON score: 0.9885

ASA_SCORE: 96.7429

COIL: 0.8089

CONS_SCORE: 0.7425

DSS_SCORE: 0.6702

HELIX: 0.1589

FCONS_SCORE: 1.0117

RIG_SCORE: 0.7101

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K363N	TCGA-AA-3984	COAD	TCGA	VLTPIKE	DEG_SCF_FBW7_2	0.3611
p.K363N	TCGA-DK-A6AW	BLCA	TCGA	VLTPIKE	DEG_SCF_FBW7_2	0.3611
p.K364N	TCGA-E6-A1LX	UCEC	TCGA	VLTPIKE	DEG_SCF_FBW7_2	0.2778
p.K371N	TCGA-EE-A183	SKCM	TCGA	VLTPIKE	DEG_SCF_FBW7_2	0.5806
p.D372G	DO48368	BLCA	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.7198
p.A375T	DO229380	BTCA	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.25
p.I357T	DO230335	COCA	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.0833
p.N364K	DO228900	LICA	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.2778
p.T374K	DO229037	LICA	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.2778
p.E379K	DO229050	LICA	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.25
p.E375K	DO48492	LIHC	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.25
p.V367I	DO23440	LINC	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.7076
p.H363L	DO27287	LUSC	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.3611
p.S362Y	DO27287	LUSC	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.2222
p.L364F	DO33091	PACA	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.2778
p.N364S	DO228721	PRAD	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.2778
p.L381S	DO37802	SKCM	ICGC	VLTPIKE	DEG_SCF_FBW7_2	0.0833
p.P369S	SIDM01117	Small Cell Lung Carcinoma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM00210	Ovarian Carcinoma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM01039	Other Solid Cancers	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM00878	Breast Carcinoma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM00257	Neuroblastoma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM00720	Mesothelioma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM01173	Rhabdomyosarcoma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.P369S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.6752
p.S380L	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.5556
p.S380L	ACH-000705	Lung Cancer	CCLE	VLTPIKE	DEG_SCF_FBW7_2	0.5556
p.S380L	ACH-001113	Lung Cancer	CCLE	VLTPIKE	DEG_SCF_FBW7_2	0.5556
p.S380L	ACH-002156	Lung Cancer	CCLE	VLTPIKE	DEG_SCF_FBW7_2	0.5556
p.S380L	LC-1-sq	lung	COSMIC	VLTPIKE	DEG_SCF_FBW7_2	0.5556
p.K373N	SIDM00309	Mesothelioma	GDSC	VLTPIKE	DEG_SCF_FBW7_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLTPIKE

Degron related mutations and impact score

Drug responses associated with CEP120 mutations

All proteins holding degron of VLTPIKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N960	Centrosomal protein of 120 kDa	DEG_SCF_FBW7_2	366:372	VLTPIKE	FBXW7	0.9885	More...