DegronMD

Uniprot ID: Q8IVF2

Source protein: Protein AHNAK2

Source gene: AHNAK2

Class: DEG_SCF_FBW7_2

Location: 4252:4258

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 79.8429

COIL: 0.7514

CONS_SCORE: 0.4311

DSS_SCORE: 0.3944

HELIX: 0.0261

FCONS_SCORE: 0.8605

RIG_SCORE: 0.7932

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4248S	TCGA-06-0744	GBM	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.2222
p.P4248S	DO11860	GBM	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.2222
p.V4256F	TCGA-39-5031	LUSC	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.5957
p.V4256F	DO26526	LUSC	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.5957
p.A4250V	TCGA-AD-6901	COAD	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.2778
p.A4250V	TCGA-AJ-A8CT	UCEC	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.2778
p.A4250V	DO9218	COAD	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.2778
p.A4250V	DO52399	UCEC	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.2778
p.T4254I	TCGA-AG-A002	READ	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.7078
p.G4247C	TCGA-D3-A2JF	SKCM	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.1944
p.G4247C	DO38153	SKCM	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.1944
p.E4265D	TCGA-EO-A22R	UCEC	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.1389
p.E4265D	DO227996	COCA	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.1389
p.E4265D	DO42713	UCEC	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.1389
p.V4256I	TCGA-EO-A22T	UCEC	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.5965
p.V4256I	TCGA-FI-A2D5	UCEC	TCGA	VMTPVVE	DEG_SCF_FBW7_2	0.5965
p.V4256I	DO42320	UCEC	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.5965
p.V4256I	DO41331	UCEC	ICGC	VMTPVVE	DEG_SCF_FBW7_2	0.5965
p.V4256I	SIDM00631	Breast Carcinoma	GDSC	VMTPVVE	DEG_SCF_FBW7_2	0.5965
p.V4256I	ACH-001358	Breast Cancer	CCLE	VMTPVVE	DEG_SCF_FBW7_2	0.5965
p.V4256I	MDA-MB-330	breast	COSMIC	VMTPVVE	DEG_SCF_FBW7_2	0.5965
p.M4264V	SIDM00538	Esophageal Carcinoma	GDSC	VMTPVVE	DEG_SCF_FBW7_2	0.1667
p.M4264V	SIDM01173	Rhabdomyosarcoma	GDSC	VMTPVVE	DEG_SCF_FBW7_2	0.1667
p.M4264V	SIDM01409	Bladder Carcinoma	GDSC	VMTPVVE	DEG_SCF_FBW7_2	0.1667
p.M4264V	TE-441-T	soft_tissue	COSMIC	VMTPVVE	DEG_SCF_FBW7_2	0.1667
p.M4264V	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	VMTPVVE	DEG_SCF_FBW7_2	0.1667
p.M4264V	ESO51	oesophagus	COSMIC	VMTPVVE	DEG_SCF_FBW7_2	0.1667
p.P4262S	SIDM00205	Ewing's Sarcoma	GDSC	VMTPVVE	DEG_SCF_FBW7_2	0.2222
p.P4262S	EW-1	bone	COSMIC	VMTPVVE	DEG_SCF_FBW7_2	0.2222
p.P4255L	SIDM00861	Ovarian Carcinoma	GDSC	VMTPVVE	DEG_SCF_FBW7_2	0.7582
p.P4255L	ACH-000906	Ovarian Cancer	CCLE	VMTPVVE	DEG_SCF_FBW7_2	0.7582
p.P4255L	ES-2	ovary	COSMIC	VMTPVVE	DEG_SCF_FBW7_2	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VMTPVVE

Degron related mutations and impact score

Drug responses associated with AHNAK2 mutations

All proteins holding degron of VMTPVVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVF2	Protein AHNAK2	DEG_SCF_FBW7_2	4252:4258	VMTPVVE	FBXW7	0.9965	More...